Principles of Management and Elements of Control Assignment - 1

Principles of Management and Elements of Control - Assignment Example The American Red Cross website can be accessed at http://www.redcross.org/. Questions have been raised about how a nonprofit organization can become more popular and effective -than other organizations such as for-profit organizations offering similar services. There are various points that account for its success and these are stipulated in the fundamental principles of Global Red Cross Network (American Red Cross 2013). One of the principles is that of Humanity, which stipulates that the teams would always work to alleviate all forms of human suffering without discriminating any affected person. The principle of humanity eventually fosters friendship, mutual understanding, peace and cohesion amongst the population it serves. The second principle is that of impartiality which prevents the team from engaging in practices that amount to discrimination based on religiosity, political stand, nationality and social and economic class. Rather, all practices should be informed by the individual needs while giving consideration to the most urgent and critical issues. The third principle, which is closely related to the principle of impartiality, is that of neutrality that bars the team from taking sides in the political, social, religious and ideological controversies. The fourth principle is that of independence. This principle guides that the team should work without undue influence from the third parties such as national politics and religiosity. This is aimed at ensuring that the teams maintain their autonomy. The fifth principle is that of Voluntary service, which rules that the team is not supposed to engage in practices that are profit oriented. The sixth principles is that of unity, which emphasizes that members of the teams should work together to realize the set goals while touching every person in  need, regardless of the country’s geographical region. The last principles are that of universality, which acknowledges that every society across the globe has an equal status and have equal responsibilities in improving the life of every person.  

ATPase Site Architecture and Helicase Mechanism Essay

ATPase Site Architecture and Helicase Mechanism - Essay Example Studies have also indicated that a means of communication takes place between the N-terminal and the C-terminal region of archaeal MCM complexes, aiding in the overall high level of conservation possessed by the complex. The beta-7 and beta-8 regions of the N-terminal are composed of highly conservative amino acid similarities, which additionally accounts for the conservative nature of the MCM protein. Although it has been mentioned that MCM proteins are largely responsible for DNA replication and helicase activity, studies indicate as well that the MCM proteins are what not only â€Å"unzip† dsDNA prior to replication but also maintain a separation between the two strands once bound together, in order to efficiently perform DNA replication and synthesis without ssDNA sticking to one another. An equally important structure, similar to MCM proteins and relavant to this topic is the GINS complex. It is necessary to touch on the function of the GINS complex when examining functions and structure of the MCM complex. The GINS complex is composed of 4 protein subunits known as paralogues. Like the MCM complex, the GINS complex is integral in DNA replication initiation and synthesis. The GINS complex works in partnership with Cdc45 (cell division control 45) in regulating the process of recruitment of DNA polymerase (pol and ) to the site of initiation and elongation. The GINS complex is also fundamental in genome duplication as shown in most vertebrates. Additional studies have indicated that the GINS complex, along with MCM proteins and Cdc45 (as well as check point factors) are all involved at replisome at paused DNA replication forks. This indicates that the human GINS complex is an equally important part of DNA replication and synthesis, to the MCM protein complex. Even more recent studies indicate that the GINS complex is present with MCM proteins 2-7 at the progressing replication fork. At this time,